Tears Naturale eye drops were discontinued

Hypromellose (hydroxypropylmethyl cellulose)Drug groupsThe hypromellose is an active ingredient from the group of cellulose derivatives, which is used in the form of eye drops as artificial tears to treat dry and irritated eyes. The drops are usually placed in the eyes several times a day. The drops are usually well tolerated.

synonymous: HypromellosumPhEur, hydroxypropylmethylcellulose, HPMC, E 464


Hypromellose is available in tear substitutes in the form of eye drops. As a pharmaceutical [excipient>] it is also contained in tablets.

Structure and properties

The hypromellose (methylhydroxypropyl cellulose) is a partial O-methylated and O- (2-hydroxypropylated) cellulose. It is available as a white, yellowish-white or gray-white powder or as grains and is practically insoluble in hot water. It dissolves in cold water to form a colloidal solution.


The hypromellose (ATC S01XA20) moisturizes the eyes. It replaces or supplements the natural tear fluid. It has thickening and emulsion stabilizing properties.

application areas

As an active ingredient:

As an auxiliary material:

As an additive:


According to the specialist information. The drops are usually placed in the eyes several times a day. See also under giving eye drops.


The complete precautionary measures can be found in the medicinal product information sheet.


No interactions are known. However, other eye drops should be administered at intervals.

unwanted effects

The drugs are usually well tolerated. Occasionally, local discomfort and allergic reactions can occur.

see also

Tear substitutes

  • Medicinal product information (CH)
  • European Pharmacopoeia PhEur
  • Specialist literature
  • Pharmaceutical Technology Textbooks
  • Product information

Conflicts of Interest: None / Independent. The author has no relationships with the manufacturers and is not involved in the sale of the products mentioned.

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This article was last changed on August 19, 2020.
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